New leads to overcome tumour relapse in basal cell carcinoma

Cedric Blanpain coordinated this study published in Nature investigating the mechanisms by which inhibition of Smoothened (acting on Hedgehog pathway) mediates tumour regression. They found that after vismodegib treatment, a small population of tumour cells expressing LGR5 persists and is responsible for tumour relapse. Combining Lgr5 lineage ablation or inhibition of Wnt signalling with vismodegib treatment leads to eradication of basal cell carcinoma.