Cancer and experimental toxicology

 

 

 

 

 

GROUP LEADER

VĂ©ronique MATHIEU

 

 

This group focuses mainly on elucidating the mechanism(s) of action of new molecules, essentially from natural origin. Indeed, Nature remains one of the major sources of new anti-cancer "lead" molecules with ~ 60% of current treatments inspired from Nature.

In particular, cellular and molecular effects are investigated using phase contrast dynamic imaging. Particular attention is paid to effective molecules on cellular models with some degree of resistance to various pro-apoptotic stimuli and especially gliomas and melanomas. In parallel, concerning targeted therapies, the group contributes to the development of strategies aiming at reducing the expression of galectin 1, a protein overexpressed by numerous cancers and involved in multiple processes of tumor development (tumorigenesis, proliferation, migration, resistance, immune system escape and angiogenesis).