Pierre P. ROGER, Ph.D
+ 32 2 555 4153
+ 32 2 555 4133
+ 32 2 555 4135
Eric RASPÉ, Ph.D.
Katia COULONVAL, Ph.D.
Sabine PATERNOT, Ph.D.
Jaime PITA, Ph.D.
Colleoni Bianca (2017) : Critical mechanisms of CDK4 activation, the key of cell cycle commitment and an essential target of oncogenic processes. Roles of p21 phosphorylations and identification of novel CDK4 activating kinases. (Adviser : P. Roger)
Using various molecular, cellular, proteomic and bioinformatic approaches, they are currently :
a) exploring the mechanisms of CDK4 regulation that determines the inactivation of the central oncosuppressor protein pRb and the cell cycle decision in normal and cancerous cells;
b) developing novel tools to predict whether cancer patients will benefit or not of treatments with the new CDK4 inhibitory drugs that are very successfully tested by several pharmaceutical companies.