« Characterisation of Esophageal Cancers and Metaplasia »
Esophageal cancers are significant health problems that account for approximately 450,000 new cancer cases annually worldwide. Esophageal cancer occurs as either squamous cell carcinoma or adenocarcinoma. To reduce the mortality rate associated with these cancers, it is crucial to better understand the origin of esophageal cancers and the molecular mechanisms underlying the development of these diseases and translate that knowledge into novel approaches for their diagnosis, prognosis and/or treatment.
The research in our laboratory is focused on two main areas:
• Characterization of the processes involved in the development of esophageal adenocarcinoma
• Identification of a molecular core in esophageal squamous cell carcinoma.
To address these questions, we use a multidisciplinary approach based on:
• Transgenic mouse models
• Conditional knockout and overexpression systems
• Lineage tracing
• 2D and 3D cell culture from mouse and human esophageal cells
• Epigenetic and transcriptomic sequencing of FACS sorted cells
• Immunostaining, in situ hybridization and qPCR
Research in Benjamin Beck’s lab is funded by the FNRS, the WELBIO, the Worldwide cancer research, the Université Libre de Bruxelles (ULB), the Région Wallonie-Bruxelles and the Télévie