Immunobiology (IBMM), ULB

 

GROUP LEADER:

Muriel MOSER, Ph.D

Muriel.Moser@ulb.ac.be

+ 32 2 650 9863

 

Group web page

                

ADMINISTRATIVE ASSISTANT:

Isabelle DECOT

idecot@ulb.ac.be

+32 2 650 9861

 

MEMBERS:

Permanent Researchers:

Oberdan LEO, PhD

Fabienne ANDRIS, PhD

Guillaume OLDENHOVE, PhD

 

PhD Students:

Caroline ABDELAZIZ

Maëlle ANCIAUX

Charlotte BISILLAT DONNET

Natalia BOWAKIM

Aurélie HANOTEAU

Coralie HENIN

Tiphène PIRNAY

Martina STEFKOVA

 

Technicians:

Valérie ACOLTY

Sébastien DENANGLAIRE

Véronique DISSY

Adrien GALUPPO

Françoise TIELEMANS

 

 

Project :

1.      Immunotherapy of cancer

There is strong evidence that the immune system can recognize tumour-associated antigens and reject established malignancies in vivo. However, ongoing studies show that induction of effector mechanisms is not sufficient to induce tumour rejection in vivo, and that strategies aimed at circumventing the negative regulatory loops that appear to dampen anti-tumour responses will be required to achieve optimal protection in cancer immunotherapy.

We are presently exploring some fundamental aspects of the anti-tumour responses in vivo, with the aim of identifying the suppressor mechanism(s) counteracting tumour resistance. Our observations suggest that the regulatory cells inhibiting anti-tumour responses represent a heterogeneous set of cells, including naturally and induced regulatory T cells and a subpopulation of cells of the innate immune system including myeloid suppressor cells. In addition, we are trying to identify the effector cells able to eradicate the P815 mastocytoma in vivo. Our results underline the major role of both CD4+ and CD8+ T cells. Their localization, specificity and function are presently under investigation.