HEAD OF UNIT:
Karen WILLARD-GALLO, PhD
+32 2 541 3739
Soizic GARAUD, PhD
Chunyan GU-TRANTIEN, PhD
Laurence BUISSERET, MD
Daphne T’KINT DE ROODENBEKE, MD
Pushpamali DE SILVA
Laurence VAN SCHOONWINKEL
1. Determine the prognostic and predictive value of detecting tumor infiltrating lymphocytes and peritumoral tertiary lymphoid structures in an effort to establish an Immunological Grade for breast cancer.
2. Investigate the molecular mediators regulating CD4+ T cells and B cells infiltrating breast tumors and the role that specific subsets of these lymphocyte populations play in the anti-tumor immune response.
3. Study the role that aberrant expression of the transcription factor FOXP1 plays in CD4+ T cell persistence and expansion, and its potential link with the development of anti-tumor immune responses.
4. Explore potential links between anti-tumor immune responses and specific mutations in triple negative breast cancer