Stem Cell and Cancer Group, ULB

 

GROUP LEADER

Cédric BLANPAIN, MD, PhD

cedric.blanpain(at)ulb.ac.be

+32 2 555 4175

 

Group web page

 

ADMINISTRATIVE ASSISTANT

Nathalie MOGUET 

nmoguet(at)ulb.ac.be

+32 2 555 4135

 

 

MEMBERS:

Permanent Researchers

Alexandra VAN KEYMEULEN, PhD

Peggy SOTIROPOULOU, PhD

 

Postdoctoral Fellows

Gaelle LAPOUGE, PhD

Marielle OUSSET, PhD

Fabienne LESCROART, PhD

Xionghui LIN, PhD

Adriana SANCHEZ-DANES, PhD

Raj GIRADDI, PhD

Mathilde LATIL, PhD

Federico MAURI, PhD

Ievgenia PASTUSHENKO, PhD

Maylis RAPHAEL, PhD

Carole MÉLIN, PhD

Manuel ZOCCO, PhD

Audrey BRISEBARRE, PhD

 

PhD Students

Andrea KARAMBELAS, MS

Maud DEBAUGNIES, MD

Soufiane BOUMAHDI, MS

Jean Christophe LARSIMONT, MS

Sophie DEKONINCK, MS

Tatiana TREVENCO, MS

Aline WUIDART, MS

Farida BENHADOU, MD

Adeline NICODÈME, MD

 

Technicians

Catherine PAULISSEN

Gaelle BOUVENCOURT

Virginie MOERS, PhD

Said LAMRANI

Christine DUBOIS

Sandrine LENGLEZ

Melanie LIAGRE

Erwin NKUSI

Sébastien DELCAMBRE

Miléna ROZZI

Anne DANNAU

Sophie LEMAIRE

 

 

PROJECTS:

 

The physiological process that maintains a constant number of cells in renewing organs is called tissue homeostasis. Stem cells located in these organs are responsible for the maintenance of tissue homeostasis during physiological condition and tissue repair following injuries. A better understanding of the mechanisms regulating stem cell function will have an important impact into the understanding and treatment of many pathological conditions such as cancer, degenerative diseases or ageing.

Our lab is studying:

Stem cells fate specification during embryonic development and tissue homeostasis

Using different models, we are studying how multipotent progenitors are specified during embryonic development, what mechanisms control the differentiation of embryonic progenitors into the different cell lineages that composed adult tissue and how tissue maintenance is ensured during homeostasis.

 

Adult stem cells during cancer initiation

For the vast majority of cancers, the cell at the origin of tumor initiation is still unknown. We are using novel genetic approach to identify the cell lineage at the origin of the most frequent epithelial cancers in humans.

 

Cancer stem cells during tumor growth and relapse

Some cancers contain cells with stem cells characteristics, and which are called cancer stem cells. We are using different approach to understand the mechanisms regulating cancer stem cell function during tumor growth and relapse after therapy.